R & D
RESEARCH ACHIEVEMENTS
기능성 식품 원료 연구
BCM 천연물 연구소는 천연물을 활용한 식품 소재를 개발하여 자연이 주는 건강함을 전달하는 것을 목표로 합니다. 이미 천연물 의약품을 개발한 바 있으며, 식약처 인정을 받은 다래추출물과 천마 등 복합추출물과 같은 개별인정형 원료 외에도 다양한 천연물의 생리활성물질을 연구하여 이를 상용화하는 데에 부단한 노력을 기울이고 있습니다.
Functional Ingredient List
- 개별인정형 원료
- 개발 진행 중 원료
다래추출물(PG102)
기능성
면역 과민반응 개선에 도움을 줄 수 있음
인정번호
분말 제 2009-18호, 액상 제 2009-58호
일일섭취량
분말 2 g, 액상 2~2.5 g
Remarks
토종 다래 유래
FDA NDI, GRAS 등재
특허청 특허기술상 세종대왕상(2016), 한국보건산업진흥원 연구부문 우수상(2008), 한국식품공업협회 한국식품환경발명대상 우수상(2010) 외
기능성
기억력 개선에 도움을 줄 수 있음
인정번호
제 2015-17호
일일섭취량
1.2 g
Remarks
천마, 단삼, 용안육, 맥문동 4가지 식물 유래
FDA NDI 등재
식물혼합추출물(EUCOMIX)
기능성
관절 및 혈행 개선 작용
Remarks
두충, 속단 등 11가지 생약 유래 일반식품 및 건강기능식품 부원료
HX109
기능성
전립선·모발 건강 개선 작용
Remarks
토사자, 연자육 및 포공영 유래
HX110A
기능성
호흡기 건강 개선 작용
Remarks
개자, 사삼, 인동 및 자소자 유래
HX110B
기능성
호흡기 건강 개선 작용
Remarks
산약, 포공영 및 형개 혼합추출물
HX112
기능성
여성 갱년기 건강 개선 작용
Remarks
길경, 갈근 유래
PG102P(HX114)
기능성
피부 건강 개선 작용
Remarks
다래, 자소엽 복합추출물
Intellectual Property
- 특허 등록
- 논문 게재
다래추출물(PG102)
면역 과민반응 개선 기능성 원료
미국
COMPOSITION COMPRISING THE EXTRACT OF ACTINIDIA ARGUTA AND RELATED SPECIES FOR THE PREVENTION AND TREATMENT OF ALLERGIC DISEASE AND NON-ALLERGIC INFLAMMATORY DISEASE
Registration No. US 9,131,722 Β2
한국
신장 질환 치료용 조성물(다래추출물을 포함하는 약학조성물)
Registration No. 10-2203926
천마 등 복합추출물(HX106)
기억력 개선 기능성 원료
한국
신경질환의 치료 및 기억력 감퇴 개선용 생약 조성물
Registration No. 10-1601860
한국
주의력결핍과잉행동장애 치료용 생약 조성물
Registration No. 10-2371285
미국
HERBAL COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASES AND IMPROVING MEMORY IMPAIRMENT
Registration No. US 10,058,583 Β2
미국
HERBAL COMPOSITION FOR TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER
Registration No. US 11,975,039 Β2
유럽
HERBAL COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASES AND IMPROVING MEMORY IMPAIRMENT
Registration No. EP 2 691 102 B1
일본
神怪疾患の治療及び記憶力改善用生葉組成物
Registration No. 5832628
HX109
전립선·모발 건강
일본
前立腺肥大症疾患の予防または治療用生薬組成物
Registration No. 7035294
HX110A
호흡기 건강
한국
호흡기 질환의 예방 또는 치료용 생약 조성물
Registration No. 10-2234040, No. 10-2410678
미국
CRUDE DRUG COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASES
Registration No. 11,559,555 B2
일본
呼吸器疾患の予防又は治療用生薬組成物
Registration No. 7249674
중국
用于预防或治疗呼吸系统疾病的生药组合
Registration No. CN 111867610 B
HX110B
호흡기 건강
한국
호흡기 질환의 예방 또는 치료용 생약 조성물
Registration No. 10-2210566
미국
CRUDE DRUG COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASES
Registration No. 11,541,097 B2
일본
呼吸器疾患の予防又は治療用生薬組成物
Registration No. 7255901
HX112
여성 갱년기 건강
한국
대사성 골질환 또는 갱년기 증상 예방 또는 치료용 조성물
Registration No. 10-2295111
일본
代謝性骨疾患又は更年期症状の予防又は治療用組成物
Registration No. 7204260
HX204
장 건강(천연물 의약품)
한국
황련 및 형개 혼합 추출물을 유효성분으로 포함하는 염증성 장질환 예방 또는 치료용 약제학적 조성물
Registration No. 10-2379395
일본
黄連及び荊芥混合抽出物を有効成分として含む炎症性腸疾患予防又は治療用薬剤学的組成物
Registration No. 7270305
중국
包含黄连及荆芥混合提取物作为有效成分的用于预防或治疗炎症性肠病的药剂学组合物
Registration No. CN 113747911 B
PG102P
피부 건강
한국
천연추출물을 포함하는 소양증의 예방 또는 치료용 조성물
Registration No. 10-2156932
다래추출물(PG102)
면역 과민반응 개선 기능성 원료
1.
Control of IgE and Th1 and Th2 cytokines by PG102 isolated from Actinidia arguta
J Allergy Clin Immunol, (2005) 116: 1151-1157
2.
Evaluation of IgE binding to proteins of hardy (Actinidia arguta), gold (Actinidia chinensis) and green (Actinidia deliciosa) kiwifruits and processed hardy kiwifruit concentrate, using sera of individuals with food allergies to green kiwifruit
Food Chem Toxicol, (2006) 44: 1100–1107
3.
Suppression of spontaneous dermatitis in NC/Nga murine model by PG102 isolated from Actinidia arguta
J Invest Dermatol, (2007) 127(5): 1154-60
4.
Subacute toxicological study of PG102, a water-soluble extract derived from Actinidia arguta, in SD rats
Korean J Vet Res, (2008) 48: 413-421
5.
Anti-allergic effects PG102, a water-soluble extract prepared from Actinidia arguta, in a murine OVA- induced asthma model
Clin Exp Allergy, (2009) 39: 280-89
6.
Suppression of allergic diarrhea in murine OVA-induced food allergy model by PG102, a water-soluble extract prepared from Actinidia arguta
Int Arch Allergy Imm, (2009) 150: 164-70
7.
Effect of PG102, a Water-soluble Extract from Actinidia Arguta on Canine Atopic Dermatitis
Kor. J. Pharmacogn, (2009) 40: 59-64
8.
A randomized, double-blind, placebo-controlled study to evaluate the effect of EFF1001 (PG102), an Actinidia arguta (hardy kiwi) preparation, on CADESI score and pruritus in dogs with mild to moderate atopic dermatitis
Vet Dermatol, (2010) 21:50-57
9.
The effects of PG102, a water-soluble extract from Actinidia arguta, on serum total IgE levels: a double-blind, randomized, placebo-controlled exploratory clinical study.
Eur J Nutr, (2011) 50: 523-529
10.
Reconstitution of anti-allergic activities of PG102 derived from Actinidia arguta by combining synthetic chemical compounds.
Exp Biol Med, (2013) 238(6): 631-40
11.
Water soluble extracts from Actinidia arguta, PG102, attenuates house dust mite-induced murine atopic dermatitis by inhibiting the mTOR pathway with Treg generation.
J Ethnopharmacol, (2016) 193: 96-106
12.
A Water-Soluble Extract from Actinidia arguta Ameliorates Psoriasis-Like Skin Inflammation in Mice by Inhibition of Neutrophil Infiltration.
Nutrients, (2018) 10: 1399
13.
PG102 Upregulates IL-37 through p38, ERK, and Smad3 Pathways in HaCaT Keratinocytes
Mediators Inflamm, (2019) 2019:6085801
천마 등 복합추출물(HX106)
기억력 개선 기능성 원료
1.
Memory improving effect of mixed herbal extract, HX106 in Alzheimer’s disease model
Planta Med, (2012) 78:PF74
2.
Ameliorating effects of HX106N, a water-soluble botanical formulation, on Aβ25–35-induced memory impairment and oxidative stress in mice.
Biol Pharm Bull, (2014) 37:954-960
3.
Effects of HX106N, a Water-Soluble Botanical Formulation on Scopolamine-Induced Memory Impairment in Mice
Korean J Food and Nutr, (2014) 27:673-677
4.
Effective suppression of nitric oxide production by HX106N through transcriptional control of heme oxygenase-1
Exp Biol Med, (2015) 240:1136-1146
5.
Effects of the Combination Herbal Extract on Working Memory and White Matter Integrity in Healthy Individuals with Subjective Memory Complaints : A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Korean J Biol Psychiatry, (2015) 22:63-77
6.
Investigation of memory‑enhancing botanical mixture and their isolated compounds for inhibition of amyloid‑β and tau aggregation
Appl Biol Chem, (2020) 63:22
7.
GC-TOF-MS-Based Metabolomic Analysis and Evaluation of the Effects of HX106, a Nutraceutical, on ADHD-Like Symptoms in Prenatal Alcohol Exposed Mice
Nutrients, (2020) 12:3027
8.
A mixed herbal extract as an adjunctive therapy for attention deficit hyperactivity disorder: A randomized placebo-controlled trial
Integr Med Res, (2021) 10:100714
HX109
전립선·모발 건강
1.
Botanical Formulation HX109 Ameliorates TP-Induced Benign Prostate Hyperplasia in Rat Model and Inhibits Androgen Receptor Signaling by Upregulating Ca2+/CaMKKβ and ATF3 in LNCaP Cells
Nutrients, (2018) 10: 1946
2.
Botanical preparation HX109 inhibits macrophage-mediated activation of prostate epithelial cells through the CCL4-STAT3 pathway: implication for the mechanism underlying HX109 suppression of prostate hyperplasia
Heliyon, (2020) 6: e04267
3.
HX109 Herbal Extract Promotes Hair Growth by Regulating Cell Cycle in Hair Follicle Dermal Papilla Cells
Asian J Beauty Cosmetol, (2023) 21(1): 107-116
HX110B
호흡기 건강
1.
Botanical formulation, TADIOS, alleviates lipopolysaccharide (LPS)-Induced acute lung injury in mice via modulation of the Nrf2-HO-1 signaling pathway
Ethnopharmacol, (2021) 270:113795
HX112
여성 갱년기 건강
1.
A mixture of Pueraria lobata and Platycodon grandiflorum extracts ameliorates RANKL-induced osteoclast differentiation and ovariectomy-induced bone loss by regulating Src- PI3K-AKT and JNK/p38 signaling pathways
Heliyon, (2024) 10(2) e24842
PG102P(HX114)
피부 건강
1.
Water-Soluble Extract from Actinidia arguta (Siebold & Zucc.) Planch. ex Miq. and Perilla frutescens (L.) Britton, ACTPER, Ameliorates a Dry Skin-Induced Itch in a Mice Model and Promotes Filaggrin Expression by Activating the AhR Signaling in HaCaT Cells
Nutrients, (2019) 11: 1366